Is There Evidence of a Therapy-Related Increase in Germ Cell Mutation Among Childhood Cancer Survivors?

摘要: Few studies have examined human population data for evidence of an association between environmental mutagens and genetic disease. Our objective was to determine whether study pregnancies offspring childhood cancer survivors would show that therapy potentially mutagenic germ cells is associated with increased risk miscarriage, serious congenital abnormalities, or altered sex ratio. We analyzed information from patients' general practitioners 2286 (1049 females 1237 males) who were exposed not direct irradiation the abdomen gonads treatment alkylating agent. In addition, external control based on used some comparisons relating abnormalities Data reproductive history complete 1037 female survivors, had 944 completed pregnancies, 1078 male produced 537 offspring. For given abdominal gonadal irradiation, there excess miscarriages total number (17%) first (19%), compared proportion in similar neoplasms such (9%) these (8%). These results re-emergence suggested our previous report miscarriage as well low birth weight among off-spring received irradiation. study, it considered unlikely due cell mutation. present do exposure ratio, occurrence therapy. However, question a possible effect will be adequately addressed only through international collaborative effort.