Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: As biomarkers and targets for new treatments.

摘要: Preclinical and clinical studies suggest that specific subsets of cells isolated from the peripheral blood, play an essential role in imbalance damage repair during age-associated diseases, such as metabolic syndrome, diabetes, atherosclerosis, neurodegenerative osteoporosis cancer. Endogenous regeneration vessel wall involves vascular wall, inflammatory cells, circulating precursors, mature endothelial which are capable to restore endothelium a concerted interaction. Early detection imbalances with biomarkers may reduce diseases subsequent cardiovascular events. Likewise, new strategies have potentiality acting selectively on these cell populations co-temporally mediate stimulation function number those regenerative action vessel, inhibit able evocate damage. These be alternative innovative way superior more efficacy biological effects than conventional attempts used for treating actually characterizing co-morbidities related ageing.