Electrospinning of aligned medical grade polyurethane nanofibres and evaluation of cell–scaffold interaction using SHED stem cells
作者： Javad Yekrang , Dariush Semnani , Mohammad H. Beigi , Saeed Karbasi
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摘要: Polyurethane (PU) nanofibres are widely used in tissue engineering of elastic tissues such as tendon and ligament, vascular arterial grafts etc. Alignment the PU is also a desirable property some to mimic morphology extracellular matrix. Elasthane™ 55D were produced using common electrospinning method rotating drum collect aligned fibres. Four flow rates five collector speeds investigated for their effects on alignment diameter. Field emission scanning electron microscopy (FESEM) images nanofibrous webs captured, diameter measured. Finally, stem cells from human exfoliated deciduous tooth (SHED) seeded surface investigate cell–scaffold interaction. Statistical results showed that rate had significant effect fibres Enhancing led increasing nanofibres. The index was promoted by speed collector. In addition, morphological observation SEM indicated grew direction this study can be applicable produce control specific applications grafts, esophagus prosthesis, ligament.
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