Energetically favorable interactions between diclofenac sodium and cyclodextrin molecules in aqueous media.
作者： S.K. Mehta , K.K. Bhasin , Shilpee Dham
DOI: 10.1016/J.JCIS.2008.06.039
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摘要: Abstract The effect of the addition cyclodextrins (CD) viz., α-, β-, HPβ- and γ-CD to aqueous solutions most widely prescribed anti-inflammatory drug, diclofenac sodium (DS), has been fully investigated by means spectroscopic (UV–vis, steady-sate fluorescence, 1H NMR ROESY) thermodynamic (conductivity) techniques. global picture results indicates that penetrates CD cavity. apparent association constants for all inclusion complexes were estimated from fluorescence data. Conductivity measurements performed both as a function DS concentration concentration, at different temperatures ranging 15 40 °C. Results suggested existence 1:1 complex between CD. thermodynamics system was discussed in terms change Gibbs free energy. Free energy DS/W found decrease on cyclodextrin, which points towards energetically favorable interactions drug cyclodextrin molecules solution phase. chemical shift changes ROESY spectra provide powerful probing CD:DS interactions.
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