Spectroscopic Study on Interaction of β‐Cyclodextrin with Triprolidine Hydrochloride
作者： Syed Mashhood Ali , Fahmeena Asmat
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摘要: The complexation of triprolidine hydrochloride (TRP) and β-cyclodextrin (β-CD) in deuterium oxide was investigated by 400 MHz 1H NMR spectroscopy. 800 2D ROESY data revealed that two 1:1 one 2:1 β-CD-TRP inclusion complexes were formed. Both aromatic moieties (p-tolyl pyridyl ring) has entered into the β-CD cavity, confirming existence different equilibria for which p-tolyl ring guest is more tightly held host cavity. ROE intermolecular interactions provided plausible structures these stoichiometric β-CD-triprolidine solution.
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