Recommended use of morphine in neonates, infants and children based on a literature review: Part 2–Clinical use

摘要: The indication for morphine use is primarily pain, but also a combined analgesic and sedative effect may be the rationale behind administration. Paediatric regimens have been reported children with postoperative pain related to cancer, sickle cell crisis burns AIDS. No dose response curve in neonates, infants or has established, different levels minimum effective plasma concentration estimated. side effects observed infants, are similar those adults, neonates do not seem more susceptible respiratory depression than older children. Despite shortcomings knowledge of pharmacodynamics morphine, it can considered safe administer Initial calculated from pharmacokinetic parameters treatment must adjusted according incidence effects.