The association between the phenotype of excessive daytime sleepiness and blood pressure in patients with obstructive sleep apnea-hypopnea syndrome.

摘要: Objective Investigate the clinical features and blood pressure (BP) pattern of phenotype excessive daytime sleepiness (EDS) in OSAHS. Methods A total 508 Chinese adults with suspected OSAHS were referred to our sleep laboratory from October 2009 May 2012. On same night polysomnography (PSG), levels measured before sleeping (bedtime BP) immediately after waking up next morning (morning BP). EDS was recognized as Epworth Sleepiness Scale (ESS)≥9. Subjects classified into four groups based on apnea-hypopnea index (AHI) PSG follows: control (simple snoring) group (control, n=104) AHI<5; mild (mild, n=89) AHI≥5 <15; moderate (moderate, n=70) AHI≥15 and<30; severe (severe, n=245) AHI ≥30. The differences correlations between BP parameters non-EDS patients analyzed. Results In all subjects, ESS positively correlated diastolic (DBP), Mean arterial (MAP) bedtime DBP (r=0.144, 0.102 0.114, respectively, each P value<0.05). patients, only (r=0.137, P<0.05). younger more likely have symptom feeling tired (36.1% vs. 23.2%, p=0.023), who had lower MSaO2, longer SIT90 (the ratio time SpO2 below 90% time) higher well morning). AHI≥15, both controlling confounding effects age, sex, BMI, nadir nocturnal oxygen saturation( r=0.126,0.143, values<0.05). And phenotype, DBP, MAP, MAP 3~5 mm Hg than that phenotype(P<0.05). group, a mean saturation (MSaO2), (P<0.05). hypertensive also micro-arousal (MiI), (P<0.05). Conclusions is special which characterized by hypoxic load. This feature mainly manifested patients. It very important identify OSAHS, may meet benefits effective treatment correcting intermittent hypoxia fragmentation.