Acidic intracellular Ca2+ stores and caveolae in Ca2+ signaling and diabetes

摘要: Acidic Ca(2+) stores, particularly lysosomes, are newly discovered players in the well-orchestrated arena of signaling and we at verge understanding how lysosomes accumulate they release it response to different chemical, such as NAADP, physical signals. Additionally, is now clear that play a key role autophagy, process allows cells recycle components or eliminate damaged structures ensure cellular well-being. Moreover, being unraveled hubs coordinate both anabolism via insulin catabolism AMPK. These acidic vesicles have close contact with ER there bidirectional movement information between these two organelles exquisitely regulates cell survival. Lysosomes also connect plasma membrane where caveolae located specialized regions involved signaling. Alterations all pathways core resistance diabetes.