Growth Differentiation Factor-15 and Risk of Recurrent Events in Patients Stabilized After Acute Coronary Syndrome: Observations From PROVE IT-TIMI 22

摘要: Objective— To investigate growth differentiation factor (GDF)-15 at hospital discharge for assessment of the risk death, recurrent myocardial infarction (MI), and congestive heart failure, to determination whether these risks can be modified by statins. Methods Results— GDF-15 is a transforming factor-β–related cytokine induced in response tissue injury. concentration associated with all-cause mortality patients acute coronary syndrome (ACS). We measured 3501 after ACS, treated moderate or intensive statin therapy PROVE IT-TIMI 22. By using established cutoff points, ( 1800 ng/L) was 2-year death MI (5.7%, 8.1%, 15.1%, respectively; P =0.24 interaction). Conclusion— events independent clinical predictors, B-type natriuretic peptide, high-sensitivity C-reactive protein. This finding supports as prognostic marker ACS investigation other therapies that modify this risk.