Hairy cell leukemia: an analysis of the chromosomes of 26 patients.

摘要: We studied the chromosomes from 26 patients with hairy cell leukemia (HCL) to ascertain frequency and types of consistent chromosomal abnormalities. Samples 21 were obtained peripheral blood cultures grown 24 48 h without phytohemagglutinin, or bone marrow samples. Two male had similar, abnormalities; one patient’s karyotype was 46, X, +12; that second +C marker. In latter case, distal long arm C marker most closely resembled chromosome No. 12 band q14 q terminal, but short proximal undetermined origin. Both karyotypes lacked Y chromosome. Nine abnormalities in single cells. One patient had, sample, a abnormal an extra 3 (48, XY, +3, +12), later poor morphology which also could have been trisomic for 12. Another unusually bright arm, as well two cells, different abnormalities, both involving 1. The rapidly progressive disease spite splenectomy, their clinical course time diagnosis relatively (5 7 months, respectively).