Chromosome Abnormalities in Malignant Diseases of the Lymphatic System

摘要: In recent years, a considerable amount of information about chromosome anomalies in relation to different malignancies has been accumulated. Prior the introduction banding methods, many authors suggested random distribution abnormalities malignant disorders; Philadelphia (Ph1) chronic myelogenous leukemia was only exception. Later, however, analysis banded karyotypes from material gave clear evidence for occurrence nonrandomly distributed changes most tumors studied thus far, and today it is well established that specific karyotypic are associated with tumor development.107