The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional acitivity

摘要: The human progesterone receptor (hPR) exists as two distinct molecular forms in most cells, hPR-A and -B. These isoforms display biological functions demonstrate a cell promoter specific ability to regulate gene transcription. In cellular contexts where is transcriptionally inactive it can function ligand dependent inhibitor of mineralocorticoid (MR) transcriptional activity. Inhibition occurs by non-competitive mechanism direct binding MR not required. Interestingly, PR agonists differ their facilitate the inhibitory hPR-A, suggesting that conformation may be preferred for this Those compounds derived from 19-nor-testosterone are effective. antiprogestins RU486, ZK98299 ZK112993 effective antagonists presence coexpressed hPR-A. mediated inhibition activity unknown. We propose results competition with common transcription factor association productive.