Evaluation of MR-proANP and copeptin for sepsis diagnosis after burn injury.
作者： Jochen Gille , Josephine Schmidt , Thomas Kremer , Armin Sablotzki
DOI: 10.1016/J.JCRC.2019.04.031
关键词:
摘要: Abstract Purpose The significance of the validated biomarkers sepsis Mid-regional pro-atrial natriuretic peptide (MR-proANP) and copeptin have not been tested in a burn injury setting. Materials methods 42 consecutive patients were included prospective observational study. Daily blood specimens collected over initial 20 days treatment quantitatively analysed by immunoluminometric sandwich assay (Kryptor, BRAHMS, Berlin, Germany) for MR-proANP, procalcitonin (PCT). Results In with absence sepsis, levels initially increased post-burn thereafter rapidly declined. contrast, MR-proANP was only slightly elevated within first few days. [199.8 (115.6; 399.5) vs 160.1 (93.7; 280.6), P Conclusion Burn itself maybe associated to lesser degree level increases. Subsequent increases may be considered diagnostic but demonstrated no advantages PCT. role remains inappropriate diagnosing after ( ClinicalTrials.gov number, NCT01055587 ).
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