Nomogram predikce up-gradingu Gleasonova skóre v biopsii prostaty

作者: D. Marek , M. Král , M. Hrabec , V. Študent , A. Vidlář

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摘要: Uvod: Tematem nasi prace bylo srovnani Gleasonova skore v biopsii a po radikalni prostatektomii za ucelem sestaveni matematickeho modelu pro přesnějsi predikci gradingu karcinomu již z uvodni biopsie.Material metody: soubor zahrnoval 159 pacientů odoperovaných na nasem pracovisti. Provedli jsme přehodnoceni i pooperacnich preparatů podle aktualnich doporuceni patologů.Výsledky: V 46,4% zařazeno mezi středně diferencovane 53,5% nizce karcinomy, zatimco pooperacne diferencovaných karcinomů pouze 21,3% oproti 78,6% karcinomů. Z výsledků posunu pooperacnim nalezem sestavili predikcni tabulku.Zavěr: prokazali zcela evidentni zlepseni histologickeho hodnoceni vyssi korelaci nalezem. Pomoci korelacnich tabulek tak lze predikovat ocekavane Gleasonovo biopsie nalez zakomponovat do rozhodovaciho algoritmu terapii prostaty.

参考文章(19)
Patrick J. Bastian, Leslie A. Mangold, Jonathan I. Epstein, Alan W. Partin, Characteristics of insignificant clinical T1c prostate tumors. A contemporary analysis. Cancer. ,vol. 101, pp. 2001- 2005 ,(2004) , 10.1002/CNCR.20586
M. Cecchi, R. Minervini, C. A. Sepich, C. Ippolito, G. L. Pagni, D. Summonti, A. Di Benedetto, L. Fiorentini, Correlation between Gleason score of needle biopsy and radical prostatectomy tissue International Urology and Nephrology. ,vol. 30, pp. 575- 580 ,(1998) , 10.1007/BF02550548
Thomas A. Stamey, Fuad S. Freiha, John E. McNeal, Elise A. Redwine, Alice S. Whittemore, Hans-Peter Schmid, Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer Cancer. ,vol. 71, pp. 933- 938 ,(1993) , 10.1002/1097-0142(19930201)71:3+<933::AID-CNCR2820711408>3.0.CO;2-L
Rodolfo Montironi, Remigio Vela Navarrete, Antonio Lopez-Beltran, Roberta Mazzucchelli, Gregor Mikuz, Aldo V. Bono, Histopathology reporting of prostate needle biopsies. 2005 update. Virchows Archiv. ,vol. 449, pp. 1- 13 ,(2006) , 10.1007/S00428-006-0190-9
FELIX K.-H. CHUN, ALBERTO BRIGANTI, SHAhROKH F. SHARIAT, MARKUS GRAEFEN, FRANCESCO MONTORSI, ANDREAS ERBERSDOBLER, THOMAS STEUBER, ANDREA SALONIA, EIKE CURRLIN, VINCENZO SCATTONI, MARTIN G. FRIEDRICH, THORSTEN SCHLOMM, ALEXANDER HAESE, UWE MICHL, RENZO COLOMBO, HANS HEINZER, LUC VALIQUETTE, PATRIZIO RIGATTI, CLAUS G. ROEHRBORN, HARTWIG HULAND, PIERRE I. KARAKIEWICZ, Significant upgrading affects a third of men diagnosed with prostate cancer: predictive nomogram and internal validation BJUI. ,vol. 98, pp. 329- 334 ,(2006) , 10.1111/J.1464-410X.2006.06262.X
GARY D. GROSSFELD, JAMES J. CHANG, JEANETTE M. BROERING, YU-PING LI, DEBORAH P. LUBECK, SCOTT C. FLANDERS, PETER R. CARROLL, Under staging and under grading in a contemporary series of patients undergoing radical prostatectomy: results from the Cancer of the Prostate Strategic Urologic Research Endeavor database. The Journal of Urology. ,vol. 165, pp. 851- 856 ,(2001) , 10.1016/S0022-5347(05)66543-3
Patrick C. Walsh, Theodore L. DeWeese, Mario A. Eisenberger, Localized Prostate Cancer New England Journal of Medicine. ,vol. 357, pp. 2696- 2705 ,(2007) , 10.1056/NEJMCP0706784
A Jenal, R Siegel, E Ward, T Murray, J Xu, C Smigal, Cancer statistics, 2002. CA: A Cancer Journal for Clinicians. ,vol. 52, pp. 23- 47 ,(2002) , 10.3322/CANJCLIN.52.1.23
Jonathan I. Epstein, Gleason score 2-4 adenocarcinoma of the prostate on needle biopsy: a diagnosis that should not be made. The American Journal of Surgical Pathology. ,vol. 24, pp. 477- 478 ,(2000) , 10.1097/00000478-200004000-00001