East and West African milk products are reservoirs for human and livestock-associated Staphylococcus aureus

摘要: Staphylococcus aureus frequently isolated from milk products in sub-Saharan Africa (SSA) is a major pathogen responsible for food intoxication, human and animal diseases. SSA hospital-derived strains are well studied but data on the population structure of foodborne S. required to identify possible staphylococcal poisoning sources lacking. Therefore, aim was assess genetic structure, virulence antibiotic resistance genes associated with milk-derived isolates Cote d’Ivoire, Kenya Somalia through spa-typing, MLST, DNA microarray analysis. Seventy three countries were assigned 27 spa (7 new) 23 (12 MLST sequence types. Milk-associated genetically diverse comprising livestock-associated clonal complexes (CCs) predominated by CC5 (n = 10) CC30 9) isolates. Panton-Valentine leukocidin, toxic shock syndrome toxin enterotoxin encoding predominantly observed among human-associated CCs. Penicillin, fosfomycin tetracycline, not methicillin detected. Our findings indicate that milk-associated originates alike highlighting need an overarching One Health approach reduce disease burdens improving production processes, care hygienic measures.