摘要: Parathyroid carcinoma is a rare entity, accounting for less than 1% of all cases primary hyperparathyroidism [1–5]. This chapter provides an overview the clinical presentation, pathophysiology, and medical surgical management parathyroid highlights some ongoing controversies areas current research interest involving this uncommon disease, including: difficulties in distinguishing benign from malignant disease both macroscopically histologically; recent developments understanding genetic basis disease; use calcimimetics other therapies nonoperative management; utility multiple reoperations patients with recurrent disease. also summarizes state knowledge regarding parathyromatosis, defined as overgrowth hyperfunctioning nodules tissue, condition which may develop after capsular fracture intraoperative seeding during tumor resection.