Transport of Glucose across the Blood-Tissue Barriers
作者： Kuniaki Takata , Hiroshi Hirano , Michihiro Kasahara
DOI: 10.1016/S0074-7696(08)62357-8
关键词:
摘要: In specialized parts of the body, free exchange substances between blood and tissue cells is hindered by presence a barrier cell layer(s). Specialized milieu compartments provided these "blood-tissue barriers" seems to be important for specific functions guarded barriers. blood-tissue barriers, such as blood-brain barrier, blood-cerebrospinal fluid blood-nerve blood-retinal blood-aqueous blood-perilymph placental endothelial or epithelial sealed tight junctions, syncytial layer(s), serve structural basis barrier. A selective transport system localized in provides needed inside GLUT1, an isoform facilitated-diffusion glucose transporters, abundant GLUT1 concentrated at critical plasma membranes barriers thereby constitutes major machinery across where occurs transcellular mechanism. composed double-epithelial layers, epithelium ciliary body case gap junctions appear play role addition transfer
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