Antimicrobial acrylic materials with in situ generated silver nanoparticles
作者： James D. Oei , William W. Zhao , Lianrui Chu , Mauris N. DeSilva , Abishek Ghimire
DOI: 10.1002/JBM.B.31963
关键词:
摘要: Polymethyl methacrylate (PMMA) is widely used to treat traumatic head injuries (cranioplasty) and orthopedic (bone cement), but there a problem with implant-centered infections. With organisms such as Acinetobacter baumannii methicillin-resistant staphylococcus aureus developing resistance antibiotics, need for novel antimicrobial delivery mechanisms without risk of resistant organisms. Objectives: To develop implant material by generating silver nanoparticles (AgNP) in situ PMMA. Results: All PMMA samples AgNP's (AgNP-PMMA) released Ag+ ions vitro over 28 days. In assays revealed that these (even the slowest release rate) inhibited 99.9% bacteria against four different strains bacteria. Long-term assay showed continued antibacterial effect past Some AgNP-loaded groups had comparable Durometer-D hardness (a measure degree cure) modulus control PMMA, all experimental slightly lower ultimate transverse strengths. Conclusions: AgNP-PMMA demonstrated tremendously broad-spectrum long-intermediate-term mechanical properties Current efforts are focused on further improving reducing AgNP loading assessing fatigue properties. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 409–415, 2012.
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