Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.

摘要: A number of dibenztropone, dibenzsuberone, dibenzoxepin, and dibenzthiepin acetic acids were synthesized tested for antiinflammatory/analgesic activity also their ability to inhibit rabbit lens aldose reductase (AR). It was found that the structural requirements activity, believed be mediated by inhibition cyclooxygenase, much more stringent than those AR inhibition. For example, introduction a hydroxyl group into positions 1, 4, 6, 7, or 8 on dibenzsuberone-2-acetic acid (1a) had relatively little effect inhibition, but caused wide variations in activity.