Analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole as potential antibacterial agents
作者： Marinella Antolini , Andrea Bozzoli , Chiara Ghiron , Gordon Kennedy , Tino Rossi
DOI: 10.1016/S0960-894X(99)00112-2
关键词:
摘要: A preliminary exploration of analogues 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole, 1, as novel antibacterial agents was carried out to determine the basic features structure responsible for observed biological activity. The presence two aryl rings, imidazole NH and either a good electron withdrawing group or an aldehyde amino at C-2 were required levels activity against methicillin resistant Staphylococcus aureus (MRSA).
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