Methods and compositions for treating hypoglycemic disorders

作者: Doris Stoffers , Diva D. De Leon , Charles Stanley

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摘要: This invention relates to methods of treating and ameliorating congenital neonatal hyperinsulinism post-prandial hypoglycemia, comprising the step administering an antagonist Glucagon-Like Peptide-1 (GLP-I) receptor, e.g. a GLP-I fragment or analogue thereof.

参考文章(60)
T. Vilsbøll, T. Krarup, S. Madsbad, J. J. Holst, No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose. Diabetic Medicine. ,vol. 18, pp. 144- 149 ,(2001) , 10.1046/J.1464-5491.2001.00424.X
Johannes Miholic, Catherine �rskov, Jens Juul Holst, Jochen Kotzerke, H. J. Meyer, Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy. Digestive Diseases and Sciences. ,vol. 36, pp. 1361- 1370 ,(1991) , 10.1007/BF01296800
JF Todd, SA Stanley, CA Roufosse, AE Bishop, B Khoo, SR Bloom, K Meeran, A tumour that secretes glucagon-like peptide-1 and somatostatin in a patient with reactive hypoglycaemia and diabetes The Lancet. ,vol. 361, pp. 228- 230 ,(2003) , 10.1016/S0140-6736(03)12256-8
Jan Tack, Joris Arts, Philip Caenepeel, Dominiek De Wulf, Raf Bisschops, Pathophysiology, diagnosis and management of postoperative dumping syndrome Nature Reviews Gastroenterology & Hepatology. ,vol. 6, pp. 583- 590 ,(2009) , 10.1038/NRGASTRO.2009.148
M. E. Patti, G. McMahon, E. C. Mun, A. Bitton, J. J. Holst, J. Goldsmith, D. W. Hanto, M. Callery, R. Arky, V. Nose, S. Bonner-Weir, A. B. Goldfine, Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia Diabetologia. ,vol. 48, pp. 2236- 2240 ,(2005) , 10.1007/S00125-005-1933-X
H. G. Cheon, W. J. LaRochelle, D. P. Bottaro, W. H. Burgess, S. A. Aaronson, High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 989- 993 ,(1994) , 10.1073/PNAS.91.3.989
J. Cancelas, J. A. García-Martínez, M. L. Villanueva-Peñacarrillo, I. Valverde, W. J. Malaisse, Resistance of succinic acid dimethyl ester insulinotropic action to exendin (9-39) amide. Hormone and Metabolic Research. ,vol. 34, pp. 13- 15 ,(2002) , 10.1055/S-2002-19960
A. B. Goldfine, E. C. Mun, E. Devine, R. Bernier, M. Baz-Hecht, D. B. Jones, B. E. Schneider, J. J. Holst, M. E. Patti, Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. The Journal of Clinical Endocrinology and Metabolism. ,vol. 92, pp. 4678- 4685 ,(2007) , 10.1210/JC.2007-0918
M. Toft-Nielsen, S. Madsbad, J. J. Holst, Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia Diabetologia. ,vol. 41, pp. 1180- 1186 ,(1998) , 10.1007/S001250051049