Genetic and Neuroanatomical Support for Functional Brain Network Dynamics in Epilepsy
作者： Pranav G. Reddy , Richard F. Betzel , Ankit N. Khambhati , Preya Shah , Lohith Kini
DOI: 10.1101/412395
关键词:
摘要: Focal epilepsy is a devastating neurological disorder that affects an overwhelming number of patients worldwide, many whom prove resistant to medication. The efficacy current innovative technologies for the treatment these has been stalled by lack accurate and effective methods fuse multimodal neuroimaging data map anatomical targets driving seizure dynamics. Here we propose parsimonious model explains how large-scale networks shared genetic constraints shape inter-regional communication in focal epilepsy. In extensive ECoG recordings acquired from group with medically refractory focal-onset epilepsy, find ictal preictal functional brain network dynamics can be accurately predicted features anatomy geometry, patterns white matter connectivity, complicit gene coexpression, all which are conserved across healthy adult populations. Moreover, uncover evidence markers non-conserved architecture, potentially driven idiosyncratic pathology single subjects, most prevalent high frequency low Finally, better more poorly geometry than dynamics, suggesting manifest seizures rely on - may directly propagate along underlying structure largely humans. Broadly, our work offers insights into generic architectural principles human impact could extended further understanding, models, predictions subject-level response intervention.
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