Spectrum of autoantibodies in celiac patients and relatives.

摘要: The coexistence of celiac disease together with a range autoimmune disorders has already been reported. aims this study were to perform broad spectrum autoantibodies in patients (N = 56), their first-degree relatives 118), and compare the data healthy controls 101) inflammatory bowel 42; Crohn's disease, N 18 ulcerative colitis, 24). All serum samples tested by indirect immunofluorescence anti-endomysium antibodies (EmA), anti-neutrophil cytoplasmic (ANCA), anti-smooth-muscle (SMA), anti-mitochondrial (AMA), anti-nuclear (ANA), anti-liver-kidney microsomal (LKM), anti-gastric parietal cells (GPCA), anti-thyroid microsome (TMA). EmA detected 100% ingesting gluten 16.1% relatives, while ANCA positive only colitis (45.6%) (16.5%). Fourteen CD (25%) for at least one other autoantibodies, significant prevalence TMA, ANA, GPCA, showed 17.8% positivity, an increased ANA TMA. These results emphasize value screening different corroborate need evaluation follow-up these individuals.