The effect of mithramycin on the multiplication of myxoviruses.
作者： C. Scholtissek , H. Becht , I. Macpherson
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摘要: Summary Mithramycin inhibited RNA synthesis in chick embryo cells culture almost as efficiently actinomycin D, although inhibition was considerably delayed. There no direct effect on cellular protein synthesis. Mithramycin interfered with the multiplication of fowl plague virus (influenza A) but had little Newcastle disease (parainfluenza). Ten µg./ml. mithramycin, when added immediately after infection, preferentially minus strand culture, it only a slight production plus RNA. The RNA-dependent polymerase and RNP-antigen slightly inhibited, while haemagglutinin neuraminidase strongly affected.
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