SYSTEMS BIOLOGY: Life's Complexity Pyramid

作者: Z. N. Oltvai

DOI: 10.1126/SCIENCE.1078563

关键词:

摘要: How are the myriad components inside cell connected together, enabling to carry out its specific functions? In their Perspective, [Oltvai and BarabAisi][1] discuss two new studies ([Lee][2] et al ., [Milo][3] .) that investigate both biological networks of intracellular nonbiological such as World Wide Web. They explain all seem be organized according same distinct principles. [1]: http://www.sciencemag.org/cgi/content/full/298/5594/763 [2]: http://www.sciencemag.org/cgi/content/short/298/5594/799 [3]: http://www.sciencemag.org/cgi/content/short/298/5594/824

参考文章(10)
Jeff Hasty, David McMillen, Farren Isaacs, James J. Collins, Computational studies of gene regulatory networks: in numero molecular biology Nature Reviews Genetics. ,vol. 2, pp. 268- 279 ,(2001) , 10.1038/35066056
Leland H. Hartwell, John J. Hopfield, Stanislas Leibler, Andrew W. Murray, From molecular to modular cell biology. Nature. ,vol. 402, ,(1999) , 10.1038/35011540
Dennis Bray, Protein molecules as computational elements in living cells Nature. ,vol. 376, pp. 307- 312 ,(1995) , 10.1038/376307A0
H. Kitano, Systems biology: a brief overview. Science. ,vol. 295, pp. 1662- 1664 ,(2002) , 10.1126/SCIENCE.1069492
Erzsébet Ravasz, Anna Lisa Somera, Dale A Mongru, Zoltán N Oltvai, A-L Barabási, Hierarchical Organization of Modularity in Metabolic Networks Science. ,vol. 297, pp. 1551- 1555 ,(2002) , 10.1126/SCIENCE.1073374
Shai S. Shen-Orr, Ron Milo, Shmoolik Mangan, Uri Alon, Network motifs in the transcriptional regulation network of Escherichia coli Nature Genetics. ,vol. 31, pp. 64- 68 ,(2002) , 10.1038/NG881
Tong Ihn Lee, Nicola J Rinaldi, François Robert, Duncan T Odom, Ziv Bar-Joseph, Georg K Gerber, Nancy M Hannett, Christopher T Harbison, Craig M Thompson, Itamar Simon, Julia Zeitlinger, Ezra G Jennings, Heather L Murray, D Benjamin Gordon, Bing Ren, John J Wyrick, Jean-Bosco Tagne, Thomas L Volkert, Ernest Fraenkel, David K Gifford, Richard A Young, Transcriptional Regulatory Networks in Saccharomyces cerevisiae Science. ,vol. 298, pp. 799- 804 ,(2002) , 10.1126/SCIENCE.1075090
Upinder S Bhalla, Ravi Iyengar, None, Emergent Properties of Networks of Biological Signaling Pathways Science. ,vol. 283, pp. 381- 387 ,(1999) , 10.1126/SCIENCE.283.5400.381
H. Jeong, B. Tombor, R. Albert, Z. N. Oltvai, A.-L. Barabási, The large-scale organization of metabolic networks Nature. ,vol. 407, pp. 651- 654 ,(2000) , 10.1038/35036627
Ron Milo, Shai Shen-Orr, Shalev Itzkovitz, Nadav Kashtan, Dmitri Chklovskii, Uri Alon, Network Motifs: Simple Building Blocks of Complex Networks Science. ,vol. 298, pp. 824- 827 ,(2002) , 10.1126/SCIENCE.298.5594.824