The human nail--barrier characterisation and permeation enhancement.

摘要: The human nail remains one of the most challenging membranes for formulation scientists to target and clinicians heal. Its formidable barrier properties are primary reason that oral therapy approach manage ungual infections. This article considers major structural underlying excellent function nail, with particular emphasis on role biophysical methods in advancing our knowledge this appendage. Formulations currently available management disease discussed their therapeutic efficacy is assessed. Finally, experimental strategies enhance permeation reviewed prospects future developments field considered.