Preclinical models of radiation-induced lung damage: challenges and opportunities for small animal radiotherapy
作者： Mihaela Ghita , Victoria Dunne , Gerard G Hanna , Kevin M Prise , Jaqueline P Williams
DOI: 10.1259/BJR.20180473
关键词:
摘要: Despite a major paradigm shift in radiotherapy planning and delivery over the past three decades with continuing refinements, radiation-induced lung damage (RILD) remains dose limiting toxicity patients receiving thoracic irradiations. Our current understanding of biological processes involved RILD which includes DNA damage, inflammation, senescence fibrosis, is based on clinical observations experimental studies mouse models using conventional radiation exposures. Whilst these have provided vital information pulmonary response, implementation small animal irradiators enabling refinements precision accuracy to mice can be applied RILD. This review presents landscape preclinical highlights challenges opportunities for further development this emerging technology study normal tissue lung.
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