Evolution of the Supermodel: Progress in Modelling Radiotherapy Response in Mice
作者： K.T. Butterworth
DOI: 10.1016/J.CLON.2019.02.008
关键词:
摘要: Abstract Mouse models are essential tools in cancer research that have been used to understand the genetic basis of tumorigenesis, progression and test efficacies anticancer treatments including radiotherapy. They played a critical role our understanding radiotherapy response tumours normal tissues continue evolve better recapitulate underlying biology humans. In addition, recent developments small animal irradiators significantly improved in vivo irradiation techniques, allowing previously unimaginable experimental approaches be explored laboratory. The combination contemporary mouse with represents major step forward for radiobiology field being able much more accurately replicate clinical exposure scenarios. As studies become ever sophisticated reflecting clinic, it is increasingly important potential limitations extrapolating data from mice This review provides an overview platforms currently as advanced radiobiological towards improving translational power preclinical studies.
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