Central monoamine dysfunction in diabetes: psychotherapeutic implications: electroanalysis by voltammetry.

摘要: The effects of chemically, i.e., streptozotocin-induced diabetes or induced hyperglycemia on dopamine and serotonin release in striatum were examined vivo rats by employing voltammetry. In the acutely diabetic state, an increased (67%) striatal was seen, whereas chronically increased, but not to same extent (19%). rat, which electrochemical signals for studied 3 days after single intraperitoneal injection STZ, responded with a significant (62%). Chronically showed reversal basal values. When L-tryptophan injected nondiabetic rats, results decrease (45%) release. Injection into produced increase (25%) over control values serotonin. maximum most evident 90 min remained elevated additional min. Long term animals (73%) L-tryptophan. inhibition 70% below baseline levels. non-diabetic decreased (52%) (304%) These changes imply that untreated state is associated progressive impairment neurotransmitter data can be interpreted as implying mood may related impaired availability state.