Schizophrenia is a diabetic brain state: an elucidation of impaired neurometabolism.

作者: R.J Holden , P.A Mooney

DOI: 10.1016/0306-9877(94)90020-5

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摘要: In this paper a detailed argument will be advanced in support of the notion that schizophrenia is fundamentally diabetic brain state, henceforth referred to as 'cerebral diabetes'. Many extraneous features cerebral diabetes have been observed, including positron emission tomography (PET) scans which reflect abnormal distribution patterns and diminished supplies glucose brain. Equally, empirical research has demonstrated plasma levels essential fatty acids prostaglandins are abnormally low, low glycoproteins urine diabetics also observed. addition, manifest wide range disturbing physical symptoms, such as, impaired sexual function, temperature control, blood pressure, disrupted sleep patterns, excessive thirst, poor memory, insensitivity pain, chronic unhappiness, all can attributed neuroendocrine function. Thus, order persuasively assert redefinition diabetes', we shall first explicate regulation transport then outline how interacts with prostaglandins, neurotransmission, system. so doing, provide metabolic explanation for prominent symptoms currently known associated indicate some future therapeutic interventions.

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