Contribution of Behavioral Risk Factors and Obesity to Socioeconomic Differences in Colorectal Cancer Incidence

摘要: who were recruited in 1995–1996 from six US states and two metropolitan areas followed through 2006. Detailed baseline data on risk factors for colorectal cancer, including health behaviors, obtained using questionnaires. SES was measured by self-reported education census-tract data. The outcome primary incident invasive adenocarcinoma. Poisson regression used to estimate the association between of with adjustment age, sex, race ethnicity, family history, state residence. model estimates derive percentage mediation behavioral factors; bias-corrected 95% confidence intervals bootstrap techniques. Results Seven-thousand six-hundred seventy-six participants developed cancer during follow-up. differences prevalence physical inactivity, unhealthy diet, smoking, weight each explained 11.3% (BMI) 21.6% (diet) 8.6% (smoking) 15.3% neighborhood cancer. Health behaviors BMI combined approximately 43.9% (95% CI = 35.1% 57.9%) 36.2% CI = 28.0% 51.2%) all largest right colon cancers smallest rectal cancers. Conclusion A substantial proportion socioeconomic disparity new-onset particularly cancers, may be attributable higher adverse low-SES populations. J Natl Cancer Inst 2012;104:1353–1362