Protection From Right- and Left-Sided Colorectal Neoplasms After Colonoscopy: Population-Based Study

摘要: BACKGROUND: Colonoscopy is used for early detection and prevention of colorectal cancer, but evidence on the magnitude overall protection according to anatomical site through colonoscopy performed in community setting sparse. We assessed whether receiving a preceding 10-year period, compared with no colonoscopy, was associated prevalence advanced neoplasms (defined as cancers or adenomas) at various sites. METHODS: A statewide cross-sectional study conducted among 3287 participants screening between May 1, 2005, December 31, 2007, from state Saarland Germany who were aged 55 years older. Prevalence ascertained by histopathologic examination any polyps excised. Previous history obtained standardized questionnaire, its association estimated, after adjustment potential confounding factors log-binomial regression. RESULTS: Advanced detected 308 (11.4%) 2701 previous 36 (6.1%) 586 had undergone within 10 years. After adjustment, site-specific adjusted ratios period follows: overall, 0.52 (95% confidence interval [CI] = 0.37 0.73); cecum ascending colon, 0.99 CI 0.50 1.97); hepatic flexure transverse 1.21 0.60 2.42); right-sided colon combined (cecum colon), 1.05 0.63 1.76); splenic descending 0.36 0.16 0.82); sigmoid 0.29 0.53); rectum, 0.07 0.02 0.40); left rectum (splenic referred left-sided elsewhere), 0.33 0.21 0.53). CONCLUSION: neoplasms, not strongly reduced even setting.