Inorganic Chemistry of Defensive Peroxidases in the Human Oral Cavity

摘要: The innate host response system is comprised of various mechanisms for orchestrating to microbial infection the oral cavity. heterogeneity cavity and associated microenvironments that are produced give rise different chemistries affect defense system. One focus this review on how these spatial differences influence two major defensive peroxidases cavity, salivary peroxidase (SPO) myeloperoxidase (MPO). With hydrogen peroxide (H(2)O(2)) as an oxidant, use inorganic ions produce antimicrobials generally more effective than H(2)O(2) itself. concentrations substrates in saliva vs. gingival crevicular fluid (GCF). Thus, supragingival regime, SPO MPO work unison exclusive production hypothiocyanite (OSCN(-), a reactive species), which constantly bathes nascent plaques. In contrast, introduced GCF during inflammatory response, environment it capable producing hypochlorite (OCl(-)), chemically powerful oxidant implicated tissue damage. A second inter-person variation may contribute function. Many attributed dietary or smoking practices alter relevant species (e.g.: fluoride, F(-); cyanide, CN(-); cyanate, OCN(-); thiocyanate, SCN(-); nitrate, NO(3)(-)). Because complexity microflora biology chemistry, difficult establish significance human systems pathogenesis diseases. problem particularly complex with respect sulcus periodontal pockets (where very stratagems co-mingle). Despite complexity, intriguing vitro vivo studies reviewed here reveal interplay between function chemistry.