Acute bouts of wheel running decrease cocaine self-administration: Influence of exercise output.

作者: Mark A. Smith , Gaylen E. Fronk , Huailin Zhang , Charlotte P. Magee , Andrea M. Robinson

DOI: 10.1016/J.PBB.2016.10.001

关键词:

摘要: Abstract Exercise is associated with lower rates of drug use in human populations and decreases self-administration laboratory animals. Most the existing literature examining link between exercise has focused on chronic, long-term exercise, very few studies have examined output (i.e., amount exercise) self-administration. The purpose this study was to examine effects acute bouts cocaine self-administration, determine whether these were dependent time interval Female rats trained run automated running wheels, implanted intravenous catheters, allowed self-administer a fixed ratio (FR1) schedule reinforcement. Immediately prior each test session, subjects engaged which they ran for 0, 30, or 60 min at 12 m/min. Acute before sessions decreased an output-dependent manner, greatest reduction intake observed 60-min condition. did not reduce when wheel separated by 12 h, responding maintained food during saline substitution test. These data indicate that decrease time- manner. results also add growing body suggesting physical activity may be effective component abuse treatment programs.

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