Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice.
作者： Steve R. Roffler , Steve R. Roffler , Suzie H. Pun , Bing-Mae Chen , Shixian Lv
DOI: 10.1016/J.JCONREL.2021.01.015
关键词:
摘要: The generation of anti-PEG antibodies in response to PEGylated proteins, peptides, and carriers significantly limits their clinical applicability. IgM antibodies mediate the clearance of …
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