Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131: The influence of cellular glutathione
作者： Orazio Sapora , Anna Paone , Antonella Maggi , Terry J. Jenner , Peter O'Neill
DOI: 10.1016/0006-2952(92)90535-Q
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摘要: Abstract Incubation of the 2-nitroimidazole-aziridine, RSU-1069 [1-(2-nitro-1-imidazolyl)-3-(1-aziridinyl) -2-propanol], and its monomethylaziridine analogue, RSU-1131 [1-(2-nitro-1-imidazolyl)-3-(1-(2-methylaziridinyl))-2-propanol], with V79-4 mammalian cells for 2hr under aerobic or hypoxic conditions induces mutations as measured at hypoxanthine phosphoribosyl transferase locus. The ability these agents to induce is increased by a factor 12–14 conditions. cytotoxicity was confirmed following 2 hr incubation period. Decreasing glutathione (GSH) content buthionine-( S , R )-sulphoximine
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