Fission yeast polycystin Pkd2p promotes transition to cell growth during cytokinesis

摘要: Polycystins are evolutionally conserved cation channels. Mutations of human polycystins lead to one the most common genetic disorders, Autosomal Dominant Polycystic Kidney Disorder. Interestingly, fission yeast homologue Pkd2p is required for cytokinesis last stage cell division, but mechanism remains unclear. Motivated by our discovery epistatic interactions between pkd2 and Hippo pathway Septation Initiation Network (SIN), we investigated their interplay during cytokinesis. We found that modulated localization as well activities SIN. Most notably, promotes a transition size growth cytokinesis, opposed The role in not limited A newly isolated temperature-sensitive mutant largely blocked tip expansion cells interphase. Such defect was accompanied frequent shrinking, reduced volume, decreased stiffness. conclude post-mitosis coordination with