A microbial TRP-like polycystic-kidney-disease-related ion channel gene
作者： Christopher P Palmer , Ebru Aydar , Mustafa BA Djamgoz
DOI: 10.1042/BJ20041710
关键词:
摘要: Ion channel genes have been discovered in many microbial organisms. We investigated a TRP (transient receptor potential) ion gene which has most similarity to polycystic-kidney-disease-related genes. shown that this (pkd2) is essential for cellular viability, and involved cell growth wall synthesis. Expression of increases following damage the wall. This fission yeast pkd2 gene, orthologues are found all eukaryotic cells, appears be key signalling component regulation shape synthesis through an interaction with Rho1-GTPase. A model mode action Schizosaccharomyces pombe protein Ca2+ pathway hypothesized.
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