Microbial TRP Channels and Their Mechanosensitivity

摘要: Publisher Summary The pioneering phenotype‐to‐gene approach that dissects biological pathways has led to transient receptor potential (TRP) channels. Follow‐up examinations of these TRPs and their homologues constitute the bulk current research on this superfamily fascinating channels are central many aspects animal physiology. Beyond animals, TRP genes can be found in Paramecium, Tetrahymena, Dictyostelium, Trypanosoma, Leishmania, other protists, as well most species fungi. Thus, basic mechanisms have evolved long before appearance multicellular animals. similarities invisible molecules distinguish only visible size, shape, movement. Man, chimp, redwood, Escherichia coli, though different size movement, made same clay. Very few macromolecules were invented since relative new comers evolutionary history. chapter summarizes presence protists If all origin conserved TM5–TM6 region holds secret, then any channel should equally appealing subject investigation.