Haploidentical hematopoietic stem cell transplantation for lymphoma with monosomy of chromosome 6 (loss of heterozygosity in the HLA region) — Who should be a donor?
作者： Kazuhiro Ikegame , Katsuji Kaida , Leif Lakoma , Shinichi Ishii , Takayuki Inoue
DOI: 10.1016/J.TRIM.2012.09.002
关键词:
摘要: Hematopoietic stem cell transplantation (HSCT) from an HLA haploidentical family donor is option for patients who do not have a full matched and lack the time to find unrelated one [1,2]. Furthermore, it may facilitate powerful graft versus leukemia/lymphoma (GVL) effect help combat hematological malignancies by directly targeting mismatched expressed on cells [3]. On contrary, escape surveillance of donor-derived GVL losing target (mismatched in GVH direction). This mechanism has been called loss heterozygosity (LOH) gene region chromosome 6 [4,5]. Taking above into account, this case report, we present lymphoma with monosomy 6, which means natural LOH HLA, suggest that selection missing haplotype seems be very effective.
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