Somatic mutations in the HLA genes of patients with hematological malignancy.

摘要: Somatic mutations and genomic alterations are frequent events in the clonal evolution of hematologic malignancies. Recent studies have reported copy neutral loss heterozygosity (LOH) for mismatched human leukocyte antigen (HLA) haplotype patients relapsed after haploidentical hematopoietic cell transplantation (HCT) a malignancy. Herein, we report 15 cases somatic HLA genes with variety diseases, including acute myelogenous leukemia, lymphocytic chronic myeloid myelodysplastic syndrome, non-Hodgkin's lymphoma, encountered at our institute over past decade. While two were identified patient relapse specimens collected post-HCT, 13 found peripheral blood submitted typing prior to transplantation. Ten exhibited acquired LOH all or part one haplotype. Five other involved nucleotide sequences common HLA-A HLA-B alleles. Since they not systematically evaluated HCT, likely under reported. Beyond implications accurate donor selection, alternations that result expression may allow escape from immune surveillance adversely impact transplant outcome.