Histopathological changes in lymph nodes of cats experimentally infected with the feline immunodeficiency virus (FIV).

摘要: Twelve specific-pathogen-free (SPF) kittens aged 8-12 weeks were serially infected in pairs every 6 weeks, by the intraperitoneal route, with feline immunodeficiency virus (FIV). Three additional SPF kept as controls. The animals killed 10 after inoculation, during primary phase of FIV infection. Generalized lymphadenopathy (GL) was observed first three cats. All lymph nodes examined from 12 cats showed histological changes. These included severe follicular hyperplasia hyperactive centres (FCs) which either (1) naked, (2) infiltrated lymphocytes, (3) seen to contain islets lymphocytic mantle cells, or (4) disrupted lymphocytes. presence both CD4+ and CD8+ T lymphocytes demonstrated FCs immunocytochemically. distribution CD4 resembled that control nodes, but CD8 cells increased number scattered clustered follicles. In addition, varying degrees interfollicular proliferation medullary plasmacytosis nodes. findings, common all animals, represented distinct prodromal manifestations changes lymphocyte subpopulation early infection reminiscent findings encountered human (HIV) reinforce suggestion is an appropriate model for study HIV pathogenesis.