Prognostic value of hedgehog signaling pathway in patients with colon cancer
作者： Meihua Xu , Xinhua Li , Ting Liu , Aimin Leng , Guiying Zhang
DOI: 10.1007/S12032-011-9899-7
关键词:
摘要: Hedgehog signaling pathway plays an important role in normal mammalian gastrointestinal development and is implicated the oncogenesis of various tumors. However, its correlation with progression prognosis colon cancer has not been well documented. This study was designed to investigate expression patterns related proteins hedgehog elucidate prognostic value this tumor. Using human their corresponding non-diseased from 228 patients' biopsies, sonic hedgehog, receptor Patched, downstream transcription factor Gli1 investigated by immunohistochemical staining assess association clinicopathological characteristics cancer. Disease-free survival overall were examined Kaplan-Meier estimates log-rank test. Prognostic factors determined multivariate Cox analysis. One hundred thirty-eight patients (59.6%) had hedgehog-positive tumors that disease-free (43.5 vs. 73.3%, P < 0.001), rates (50.7 88.9%, 0.001) much lower than those hedgehog-negative In addition, 163 (71.5%) Patched-positive tumors, (41.7 76.9%, (55.2 80.0%, = 0.002) also Patched-negative Moreover, positive a bad effect on (41.9 73.2%, rate (50.0 89.3%, 0.001). analysis, status indicators for poor survival. These results have shown increasing are first report describing about relationship between
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