Association Between Anticholinergic Drugs and Apolipoprotein E ɛ4 Allele and Poorer Cognitive Function in Older Cardiovascular Patients: A Cross-Sectional Study

摘要: OBJECTIVES: To clarify the association between anticholinergic drugs and apolipoprotein E ɛ4 allele carrier status (APOE4) cognitive dysfunction. DESIGN: Cross-sectional analyses of current drug use functioning according to baseline assessments Drugs Evidence-Based Medicine in Elderly Study. SETTING: Helsinki, Finland. PARTICIPANTS: Four hundred community-dwelling people aged 75 90 without clinical dementia but with a history stable atherosclerotic disease. MEASUREMENTS: Cognitive function Mini-Mental State Examination (MMSE) Clinical Dementia Rating Scale (CDR). Participants' was estimated using definitions from previous scientific literature. APOE alleles determined peripheral blood leukocyte deoxyribonucleic acid standard polymerase chain reaction–based methods. RESULTS: There an lower MMSE scores (P for trend <.001). The higher number drugs, score. Subjects APOE4 properties had lowest median score (26), whereas those not highest (28). When adjusted age, sex, education, difference groups remained significant. finding similar CDR scores. CONCLUSION: Use associated irrespective status. Having as group, carriers may be more vulnerable this undesirable effect, follow-up study is needed demonstrate this.