Lower urinary tract dysfunction in patients with parkinsonism and other neurodegenerative disorders

摘要: Progressive neurodegenerative disorders are devastating diseases with often fatal outcomes. Lower urinary tract symptoms (LUTS) add to morbidity and increase the risk of becoming dependent on help others (e.g., nursing-home referral). In Parkinson's disease (PD), specific loss dopaminergic neurons in substantia nigra possibly also ventral tegmental area induces neurogenic bladder control through dysfunction a complex network which selective disinhibition reflexes is lost. PD, more than 60% patients have troublesome symptoms, 30% experience incontinence, though not daily. atypical parkinsonism, including multiple system atrophy, LUTS highly prevalent, onset comparison other autonomic motor may serve as diagnostic marker. Less known about pathophysiology incontinence Alzheimer's disease, but higher cognitive function attention self-management play role. Incontinence major factor for independence. The pathophysiologic mechanisms hence important roles patient quality life. Nocturia, urgency well poor emptying most common symptoms. These interact core disorders, increasing infection. rarer neurogenerative disorder be present, commonly spinal cord involvement. systematic careful tracking evaluation using non-invasive techniques, conservative management pharmacologic treatments can markedly improve lives their caregivers.