Genitourinary Dysfunction in Multiple System Atrophy: Clinical Features and Treatment in 62 Cases

摘要: Multiple system atrophy is a disorder characterized by progressive neuronal at certain sites of the central nervous system, several which are important in control urogenital function. The neuro-urological features 62 patients with this condition described. All had abnormal urethral or anal sphincter electromyography when individual motor unit analysis was performed, finding diagnostic appropriate clinical setting. Impotence occurred 96% men and first symptom alone 37%. Urinary symptoms resulted from combination detrusor hyperreflexia weakness followed failure contraction. In these simulated those outflow obstruction so that 43% underwent prostatic bladder neck surgery before correct diagnosis made. Stress incontinence 57% women half undergone surgery. results both sexes were poor. Treatment intermittent catheterization, anticholinergic medication desmopressin spray markedly improved continence 82%. importance recognizing introducing effective, nonoperative treatments stressed.