Multiple system atrophy
作者： Gregor K. Wenning , Florian Krismer
DOI: 10.1016/B978-0-444-53491-0.00019-5
关键词:
摘要: Multiple system atrophy (MSA) is a sporadic and fatal α-synuclein-linked oligodendrogliopathy manifesting with progressive autonomic failure, poorly levodopa-responsive parkinsonism, cerebellar ataxia, in any combination. Here we review key aspects of MSA integrating important insights from rapidly emerging fields such as genetics, diagnostic work-up including imaging, translational therapies aimed at disease modification.
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