Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury.
作者： HayderM Al-Kuraishy , AliI Al-Gareeb , NawarR Hussien
DOI: 10.4103/IJCIIS.IJCIIS_85_18
关键词:
摘要: Objective: To evaluate the renoprotective effects of berberine and/or pentoxifylline in reduction diclofenac-induced acute kidney injury (AKI) rats. Material and Methods: Fifty male Sprague-Dawley rats were allocated into five groups, Group 1: Rats treated with distilled water plus normal saline for 12 days. 2: diclofenac 3: 4: 5: + 15 mg/kg Blood urea, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), molecules (KIM-1), cystatin-c used to measure severity AKI. Results: Diclofenac led significant AKI by elevation blood serum KIM-1, NGAL. Treatment showed no effect on all biomarkers level compared group except KIM-1 which also seen whereas combination more renal biomarkers. Conclusion: Combination illustrated a synergistic attenuation
ijciis.org参考文章(22)
Roy Altman, Bill Bosch, Kay Brune, Paola Patrignani, Clarence Young, Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. ,vol. 75, pp. 859- 877 ,(2015) , 10.1007/S40265-015-0392-Z
M Bickel, P Khaykin, C Stephan, K Schmidt, M Buettner, K Amann, T Lutz, P Gute, A Haberl, H Geiger, HR Brodt, O Jung, Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration. Hiv Medicine. ,vol. 14, pp. 633- 638 ,(2013) , 10.1111/HIV.12072
Arunachalam Muthuraman, Amteshwar Singh Jaggi, Nirmal Singh, Kuldeep Grover, Ravi Dhawan, Amrit Pal Singh, Animal models of acute renal failure Pharmacological Reports. ,vol. 64, pp. 31- 44 ,(2012) , 10.1016/S1734-1140(12)70728-4
Asjad Visnagri, Amit D Kandhare, Subhash L Bodhankar, None, Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation. Renal Failure. ,vol. 37, pp. 482- 493 ,(2015) , 10.3109/0886022X.2014.996843
Virginia Brown, Effect of pentoxifylline on preventing acute kidney injury after cardiac surgery by measuring urinary neutrophil gelatinase - associated lipocalin Journal of Cardiothoracic Surgery. ,vol. 6, pp. 8- 8 ,(2011) , 10.1186/1749-8090-6-8
Juan F. Navarro-González, Mercedes Muros, Carmen Mora-Fernández, Haridian Herrera, Beatriz Meneses, Javier García, Pentoxifylline for Renoprotection in Diabetic Nephropathy: the PREDIAN study. Rationale and basal results Journal of Diabetes and Its Complications. ,vol. 25, pp. 314- 319 ,(2011) , 10.1016/J.JDIACOMP.2010.09.003
E L B Novelli, Y S Diniz, C M Galhardi, G M X Ebaid, H G Rodrigues, F Mani, A A H Fernandes, A C Cicogna, J L V B Novelli Filho, Anthropometrical parameters and markers of obesity in rats Laboratory Animals. ,vol. 41, pp. 111- 119 ,(2007) , 10.1258/002367707779399518
Lesley A Inker, Christopher H Schmid, Hocine Tighiouart, John H Eckfeldt, Harold I Feldman, Tom Greene, John W Kusek, Jane Manzi, Frederick Van Lente, Yaping Lucy Zhang, Josef Coresh, Andrew S Levey, None, Estimating glomerular filtration rate from serum creatinine and cystatin C. The New England Journal of Medicine. ,vol. 367, pp. 20- 29 ,(2012) , 10.1056/NEJMOA1114248
George J. Schwartz, Alvaro Muñoz, Michael F. Schneider, Robert H. Mak, Frederick Kaskel, Bradley A. Warady, Susan L. Furth, New Equations to Estimate GFR in Children with CKD Journal of The American Society of Nephrology. ,vol. 20, pp. 629- 637 ,(2009) , 10.1681/ASN.2008030287
T. Mizuno, K. Ito, Y. Miyagawa, K. Ishikawa, Y. Suzuki, M. Mizuno, Y. Ito, Y. Funahashi, R. Hattori, M. Gotoh, K. Yamada, Y. Noda, Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomy in elderly patients. Japanese Journal of Clinical Oncology. ,vol. 42, pp. 1073- 1078 ,(2012) , 10.1093/JJCO/HYS145