The Preparation and Characterization of Amphiphilic Star Block Copolymer Nano Micelles Using Silsesquioxane As the Core
作者： Caihua Ni , Geng Wu , Changping Zhu , Bolong Yao
DOI: 10.1021/JP103260H
关键词:
摘要: Amphiphilic star-shaped block copolymers of poly(e-caprolactone-star-N-isopropylacrylamide) were synthesized by using hydroxyl-functionalized polyhedral oligomeric silsesquioxanes (POSS) as a core to initiate ring-opening polymerization e-caprolactone, followed atom transfer radical N-isopropylacrylamide. The sizes the and shell could be controlled through adjusting feed ratios reactants. structure star confirmed FTIR, 1HNMR, 29SiNMR, DSC. Nano micelles formed adding water copolymer solution (DMF). critical concentration for formation determined UV. results TEM DLS showed that well-defined three-dimensional spherical particles with an average diameter 155 nm. A hydrophobic drug ibuprofen loaded on effectively, release behavior was temperature dependent.
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