Biodegradable micelles self-assembled from miktoarm star block copolymers for MTX delivery
作者： Qing-Han Zhou , Juan Lin , Li-Dong Li , Le Shang
DOI: 10.1007/S00396-015-3610-Z
关键词:
摘要: Biodegradable micelles based on disulfide-linked monomethoxy poly(ethylene glycol)-b-poly(methyl methacrylate)2 (mPEG-SS-PMMA2) miktoarm star block copolymers were synthesized through atom transfer radical polymerization procedure and applied to solubilization delivery of methotrexate (MTX). The characterized by 1H nuclear magnetic resonance, Fourier transform infrared spectra, gel permeation chromatography. able self-assemble into spherical in water with an average diameter up 130 nm transmission electron microscopy observation dynamic light scattering measurements have a critical micelle concentration 0.91 mg/L. When MTX was incorporated obtained micelles, high drug loading capacity found attributed the designed star-shaped nanostructure. Interestingly, presence dithiothreitol, could be degraded polymer chains cleavage disulfide linkages. vitro release studies revealed that these released over 95 % within 48 h under reductive environment analogous cell comparing minimal (<22 %) nonreductive conditions. Cell cytoxicity experiments showed exhibited nontoxic, drug-loaded anticancer efficacy better biocompatibility as compared free MTX. All results mPEG-SS-PMMA2 are promising carriers for hydrophobic antitumor drugs.
springer.com
sci-hub.se 参考文章(42)
Yong Sun, Yihang Huang, Shaoquan Bian, Jie Liang, Yujiang Fan, Xingdong Zhang, Reduction-degradable PEG-b-PAA-b-PEG triblock copolymer micelles incorporated with MTX for cancer chemotherapy. Colloids and Surfaces B: Biointerfaces. ,vol. 112, pp. 197- 203 ,(2013) , 10.1016/J.COLSURFB.2013.07.056
Abdallah Laouini, Konstantinos P. Koutroumanis, Catherine Charcosset, Stella Georgiadou, Hatem Fessi, Richard G. Holdich, Goran T. Vladisavljević, pH-sensitive micelles for targeted drug delivery prepared using a novel membrane contactor method. ACS Applied Materials & Interfaces. ,vol. 5, pp. 8939- 8947 ,(2013) , 10.1021/AM4018237
L. Zhang, K. Yu, A. Eisenberg, Ion-Induced Morphological Changes in “Crew-Cut” Aggregates of Amphiphilic Block Copolymers Science. ,vol. 272, pp. 1777- 1779 ,(1996) , 10.1126/SCIENCE.272.5269.1777
Caihua Ni, Geng Wu, Changping Zhu, Bolong Yao, The Preparation and Characterization of Amphiphilic Star Block Copolymer Nano Micelles Using Silsesquioxane As the Core Journal of Physical Chemistry C. ,vol. 114, pp. 13471- 13476 ,(2010) , 10.1021/JP103260H
Juan Lin, Qing-Han Zhou, Li-Dong Li, Zhi-Nian Li, Synthesis and self-assembly in bulk of star-shaped block copolymers based on helical polypeptides Colloid and Polymer Science. ,vol. 292, pp. 3177- 3185 ,(2014) , 10.1007/S00396-014-3345-2
Dawanne E. Poree, Marco D. Giles, Louise B. Lawson, Jibao He, Scott M. Grayson, Synthesis of Amphiphilic Star Block Copolymers and their Evaluation as Transdermal Carriers Biomacromolecules. ,vol. 12, pp. 898- 906 ,(2011) , 10.1021/BM101185T
Rujiang Ma, Hao Yang, Zhong Li, Gan Liu, Xiaocheng Sun, Xiaojun Liu, Yingli An, Linqi Shi, Phenylboronic acid-based complex micelles with enhanced glucose-responsiveness at physiological pH by complexation with glycopolymer. Biomacromolecules. ,vol. 13, pp. 3409- 3417 ,(2012) , 10.1021/BM3012715
Xin Sui, Zhenyu Zhang, Song Guan, Yawei Xu, Chao Li, Yufeng Lv, Aihua Chen, Lijun Yang, Longcheng Gao, A facile strategy for the synthesis of block copolymers bearing an acid-cleavable junction Polymer Chemistry. ,vol. 6, pp. 2777- 2782 ,(2015) , 10.1039/C5PY00058K
M. Jäger, A. Wilke, Comprehensive biocompatibility testing of a new PMMA-hA bone cement versus conventional PMMA cement in vitro. Journal of Biomaterials Science-polymer Edition. ,vol. 14, pp. 1283- 1298 ,(2003) , 10.1163/156856203322553491
Juan Lin, Jian-Bin Luo, Sheng-Tao Yang, Qing-Han Zhou, Template-directed self-assembly of a designed amphiphilic hexapeptide on mica surface Colloid and Polymer Science. ,vol. 291, pp. 2263- 2270 ,(2013) , 10.1007/S00396-013-2969-Y